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the FL emission intensity of the light progressively increased without emission wavelength shifting

Additionally, TRIM16 overexpression enhances the expression of several antioxidant genes, including glutamatecysteine ligase catalytic subunit (GCLC), glutamatecysteine ligase modifier subunit (GCLM), HO-1, NADPH, and GPX2

Having validated that combined inhibition of GLUT1 and GCL synergistically induced cell death in xCT-high GBM and Ewings sarcoma cell lines, we next sought to identify other cancer types which might exhibit sensitivity to this drug combination

doi:10.1038/nature07534 pmid:19052620 Delarasse C, Auger R, Gonnord P, Fontaine B, Kanellopoulos JM (2011) The purinergic receptor P2X7 triggers alpha-secretase-dependent processing of the amyloid precursor protein

As GSH acts as a major antioxidant in the brain, this impaired GSH redox status can lead to further oxidative damage and redox dysregulation, which is associated with cognitive deficits, neuronal death, and mortality in animal epilepsy models